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Several clinical trials are examining all these different classes to increase or restore the activity of the mutated CFTR protein in patients (Clancy et al., Besides the general overlook of the main CFTR modulators reported in this section, many other therapeutic agents based on correctors and potentiators are undergoing various pre-clinical and clinical studies, and are extensively described by Rafeeq and Murad (2017)

Some abnormal plasma elevations of hemostatic parameters, including factor VIII (Freyburger et al, 1997), von Willebrand factor (van den Berg et al, 1995), fibrinogen (von Eckardstein et al, 1994), thrombomodulin (van den Berg et al, 1995), thrombin/antithrombin III complex and activated protein C (Cattaneo, 1999

J Endocrinol, 2024

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